Selected Clinical Data and References for Procedures Related to
The Vascular Designs Approach of Directed Infusion of Chemotherapy

Overall Review of Clinical Data

Stop-flow technique for loco-regional delivery of antiblastic agents: Literature review and personal experience

Pharmacologic rationale for regional drug delivery

Advanced concepts in chemotherapy drug delivery: Regional therapy

Regional chemotherapy: Theory and practice

Regional chemotherapy: Clinical research and practice

Abdominal

Treatment of unresectable malignant abdominal, pelvic and thoracic tumors using abdominal pelvic and thoracic stop-flow chemotherapy

Colorectal

Regional chemotherapy of non-resectable liver metastases from colorectal cancer: Literature and institutional review

Multimodality approach towards advanced rectal carcinoma: Its efficacy and safety

Gallbladder

Aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer

Gastric

Upper abdominal stop-flow perfusion as a neo and adjuvant hypoxic regional chemotherapy for resectable gastric carcinoma: A prospective randomized clinical trial

Gastrointestinal

Intraaortic stop-flow infusion: Pharmacokinetic feasibility study of regional chemotherapy for unresectable gastrointestinal cancers

Locally Advanced Tumors

Hypoxic antiblastic stop-flow perfusion: Clinical outcome and pharmacokinetic findings

Liver

Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies

Percutaneous hepatic perfusion with melphalan for patients with metastatic melanoma to the liver

Does chemotherapy given directly to the liver improve survival in patients with hepatic metastasis?

Lymphoma

Stop-flow in mediastinum and thorax for resistant lymphoma

Melanoma

Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: A pilot study

Pelvis

Stop-flow technique for loco-regional delivery of high dose chemotherapy in the treatment of advanced pelvic cancers

Ovarian

Abdominal stop flow infusion breaks drug resistance in systemically pretreated progressive FIGO IIIc and IV ovarian cancer

Small Cell Lung Cancer

Thoracic stop-flow perfusion in the treatment of refractory non small cell lung cancer

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